Best Vayne Build Guide | Runes | Spells | Items in League of Legends

Vayne is a late game glbutt cannon that can demolish the enemy team with ease but needs lots of babysitting during the early game by peel focused supports!

Updated on Sep 11, 2023
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Best Vayne Build Guide | Runes | Spells | Items in League of Legends

Ever-since Riot games released Vayne, she has dominated the bot lane. In the hands of a good Vayne player, she is an unstoppable late game monster that can solo the entire enemy team. She easily deals with tanks with her silver bolts and chase enemies with night hunter. Learn how to play her in the best league of legends vayne build guide.

Best Vayne Build

Vayne’s build focuses on empowering her auto attack. Silver bolts is a pbuttive ability that makes Vayne a strong 1v1 champion. Therefore, working around that on runes and item build will most likely make her unstoppable. In this build, we are going to start with the best runes for Vayne which has a win rate of 54.4% in patch 12.15.


Best Vayne Runes

Vayne is a precision rune set abuser through and through. Her kit revolves around the bonuses that precision gives. Lethal Tempo keystone rune gives her more and more attack speed the longer she fights making her deal more attack damage per second. Once Lethal tempo is fully stacked, it also gives her bonus range perfect for kiting and chasing.

Best Rune Path



Best Keystone

Lethal Tempo

Best Slot 1 (Rune)

Presence of Mind

Absolute Focus

Best Slot 2 (Rune)


Gathering Storm

Best Slot 3 (Rune)

Coup de Grace

Presence of mind and Bloodline however is Vayne’s lifeline during the early game. You can abuse Vayne’s Q tumble with presence of mind and Bloodline also gives her a boost in sustainability.

Best Vayne Rune Shards

Vayne ADC relies on her right clicks so a point on attack speed from offense and +9 adaptive force or attack damage from flex is pretty customary. This goes very well with Vayne’s rune build as she is lacking Legend: Alacrity from her runes.

Best Rune Shards



+10 Attack Speed


+9 Adaptive Force


+6 Armor

With more attack speed, Vayne can also proc her silver bolts more often making it easier for her to kill her enemies. This is also the reason why Vayne needs more attack speed than damage, simply because using silver bolts is much stronger than letting Vayne deal more auto attack damage.

Best Vayne Spells

Summoner spells for right click reliant ad carry champions are pretty much the same with the heal and Flash combo. Both of these summoner spells give Vayne more mobility and movement speed when kiting or disengaging.

Best Spells





Best Vayne Abilities Order

Vayne’s Skill order starts with a Silver bolts as her priority to maximize. This ability empowers her basic attacks against squishy enemies or even tanky ones. Next up is Vayne’s Q tumble because this is an ability that she can use to poke or even chase enemies.


This skill order also synergizes with Vayne’s night hunter pbuttive which can also be improved by her Final Hour ultimate. Both of these abilities allow Vayne to move faster toward enemies while she deals true damage to them.

Best Vayne Items

In this League of Legends Vayne build, you will be focusing on having enough survivability and proccing the effects of Vayne’s W more often. Vayne is well known for having a very strong power spike with building just one item. Find it out with the best Vayne build of Patch 12.15.

Best Starter Vayne Items

Vayne ADC early game item build consists of a Doran’s blade and a health potion. Both of these item provide great sustainability for Vayne until she reaches her power spike with her core build.

First Item

Second Item

Doran’s Blade

Health Potion

Best Mid Game Vayne Items

Every Vayne abuser only rushes one item on her and that is Guinsoo’s Rageblade, this item allows her to activate her W faster. Immortal Shieldbow and Berserker’s Greaves give Vayne even more attack speed.

First Item

Second Item

Third Item

Immortal Shieldbow

Berserker’s Greaves

Guinsoo’s Rageblade

Kraken slayer is a great alternative among other mythic items for Vayne because this item allows her to deal bonus true damage on the third strike. This item allows her to scale better but it makes her extremely squishy.


Best Final Late Game Vayne Items

Now that her core items are complete during the mid game, her second core items are the ones that you use to counter your enemies. Blade of the Ruined king is a core item that works really well no matter what type of enemy Vayne is facing. Blade of the Ruined King also gives her physical vamp.

First Item

Second Item

Third Item

Fourth Item

Fifth Item

Sixth Item

Immortal Shieldbow

Berserker’s Greaves

Guinsoo’s Rageblade

Wit’s End

Blade of the Ruined King

Phantom Dancer

Wit’s end and Phantom Dancer both improve Vayne’s on-hit potential but both can be replaced by Vayne’s other core items Guardian angel and Randuin’s Omen. This two alternative items are great for when Vayne is facing enemies with higher burst potential than her.

Best Champions to pair Vayne with

Vayne needs excessive babysitting during the early to mid game so she can carry hard for the late game. So champions that can peel for her are the best ones to partner her with. Fiddlesticks’ Q disables enemy gankers for a long time making it useless for them to gank Vayne’s lane.


Win Rate %








Strongest Champions against Vayne

Riot Games’ counter matchup mechanic is really great because no matter how overpowered a champion is, there will always be a champion stronger than that. In Vayne’s case, Zeri, Kalista, and Xayah all have above 50% win rate against Vayne simply because their kit counter’s her basic attack reliant nature. These champions are also great for team fights that stomp Vayne during one.


Win Rate %








Weakest Champions against Vayne

The champions that you should avoid when playing against Vayne are the ones that can be easily chased with her pbuttive night hunter and movement impaired by blade of the ruined king. For this reason, Draven is a really weak champion against Vayne. Sure he can outdamage Vayne but once Vayne completes her item power spike, Draven won’t be able to do much.


Win Rate %








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