Best Vex Build Guide | Runes | Spells | Items in League of Legends

Vex deals tons of magic damage against her enemies and is very mobile with her ultimate especially when she scores a takedown and resets its cooldown!
Best Vex Build Guide | Runes | Spells | Items in League of Legends

Vex mid is an insanely powerful burst mage that can easily secure a pentakill when she resets the cooldown of her ultimate on champion takedown. She is a small and emo kind of champion released by Riot games back in 2021. Learn how to play vex mid this patch 12.16 with this Vex build guide. 

Best Vex Build

This build will focus on Vex mid and how she can easily win her lane and have a global impact on the map. First, we'll show you the best vex runes and best skill order to take.

Vex Build

Best Vex Runes

Vex has a really long range in the early game perfect for poking and proccing Electrocute. Her long ranged abilities can also be used to activate the heal from taste of blood.

Best Rune Path



Best Keystone


Best Slot 1 (Rune)

Taste of Blood

Manaflow Band

Best Slot 2 (Rune)

Eyeball collection


Best Slot 3 (Rune)

Ultimate hunter

Ultimate hunter along with Eyeball collection will both find their value in the mid-game as Vex scores takedowns. Both of these abilities will make Vex stronger in the late game.

Best Vex Rune Shards

For Vex's rune shards, one point on Adaptive force and attack speed will help her secure early game CS. The defense slot though depends on whether your enemy champion in the mid-lane is an AD or AP champion.

Best Rune Shards



+10 Attack Speed


+9 Adaptive Force


+8 Magic Resist

Best Vex Spell

For Vex's summoner spells, a flash and an ignite will give her an extremely high kill pressure. She has a great all-in potential when she reaches level 6. Out of all summoner spells, nothing beats Ignite when you want to win your lane in the early game. 

Best Spells




Vex Mistral Bolt Q

Best Vex Abilities Order

Vex players really want to deal heavy damage with these champions so Mistral Bolt will be the first ability to be maxed on Vex. This ability has a very low cooldown of 4 seconds when maxed out making you deal damage quite often in lane.

Personal space or Vex's W comes next as you can use this every time an enemy tries to poke you. This ability gives you a shield and also has damage. Looming Darkness comes last simply because it is really hard to hit and easy to dodge. 

Best Vex Items

Personal space, Looming Darkness, and Mistral Bolt all have AP scaling meaning the higher your ability power is the more damage you can deal. Vex already has high base damage from her abilities thanks to her low cooldowns and cooldown resets, and because of this, you should focus on building magic penetration items like 

Best Starter Vex Items

In league of legends, there are designated starter items for each role, and Vex being an AP champion, she can start with a Doran's Ring and a health potion. 

First Item

Second Item

Doran’s Ring

Health Potion

Best Mid Game Vex Items

Luden's Tempest is the best of all mythic items in the game for Vex, it improves her manapool and is really great for poking. Sorcerer's Shoes and Shadowflame will both melt tank champions with high Magic Resist stats. 

First Item

Second Item

Third Item

Luden’s Tempest

Sorcerer’s Shoes


Vex Ultimate Ability

Best FInal Late Game Vex Items

Vex can be really squishy during the late game and that is why Zhonya's hourglass will be a great purchase. Rabadon's Deathcap is the item that gives the highest ability power in league of legends and once you build this item, you will be able to double your damage output.

First Item

Second Item

Third Item

Fourth Item

Fifth Item

Sixth Item

Luden’s Tempest

Sorcerer’s Shoes


Zhonya’s Hourglass

Rabadon’s Deathcap

Void Staff

Void Staff finishes this Vex build and is quite optional. Void staff is a great purchase if there are tanks that have really high magic resist. The percentage magic penetration this item provides will make it look like Tanks don't have magic resist stats.

Best champions to pair Vex with

Volibear, Master Yi, and Bel'veth all have something in common in league of legends. They all have excellent gap-closing abilities and are great at tower diving. Vex tends to tower dive with her ultimate and these junglers can help her kill champions really fast or disable the tower for a successful gank. 


Win Rate %




Master Yi




Strongest Champions against Vex

Vex has a linear engage thanks to her ultimate ability, Cassiopeia can easily counter her whenever Vex decides to engage with her ultimate. Swain's lane dominance and high kill pressure beat Vex's.


Win Rate %








Weakest Champions against Vex

These champions are really squishy at whatever point of the game you're in. Vex can easily outmaneuver and chase them with her ultimate and her passive, doom n gloom can leave them vulnerable every time Vex decides to go all-in. Doom n gloom can also be great when poking to avoid the poke retaliation of these champions. 


Win Rate %








Vex has a 55.6% win rate in patch 12.16 and is really quite high for a champion with really low ban rate. Vex is a simple champion and can be easily mastered. Once you know the best runes and items to build on her, you can immediately dominate your solo queue games. 

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