Best Cassiopeia Build Guide | Runes | Spells | Items in League of Legends

Riot Games has its own fair share of unique designed champions, and Cassiopeia is one of them. She is one of the most mechanically demanding mid-lane champions ever released in League of Legends. If you are looking to main the snake-themed champion, then follow this Cassiopeia build, runes, spells, and items guide!

Best Cassiopeia Build

Cassiopeia is picked a lot in pro play, so some might be tempted to pick her right away just by seeing their favorite player perform an amazing outplay. However, as mentioned previously, she is one of the hardest champions to play. Still, she is also one of the most rewarding and provides extreme value for the team at all stages of the game. Follow this guide carefully to get the most out of her!

Best Cassiopeia Runes

Now, Cassiopeia mid is tough to master, but these rune set will make it more manageable, so make sure you copy everything and adjust them according to the matchup.

BEST RUNE PATH	PRECISION	RESOLVE
Best Keystone	Conqueror
Best Slot 1 (Rune)	Peace of Mind	Conditioning #
Best Slot 2 (Rune)	Legend: Tenacity	Overgrowth
Best Slot 3 (Rune)	Coup De Grace

The best rune page for Cassiopeia is pretty unconventional because not all ability power champions use conqueror as their main rune. However, this is the best primary rune for her because she stacks conqueror really fast with her twin fang.

Cassiopeia has a subpar early game, and the supporting runes will make it easier during the laning phase because of the sustain (Presence of Mind, Legend: Tenacity, Conditioning, and Overgrowth) and additional damage (Coup de Grace)

Best Cassiopeia Rune Shards

Cassiopeia's rune shard choice is simple. As an ability power carry, Cassiopeia players should always go for the offense shard, which gives additional ability power.

These rune shards make it easier to poke during the laning phase. It is also not recommended to go for defensive rune shards because Cassiopeia's range makes it harder for enemies to reach her, thus not being able to deal a lot of damage.

BEST RUNE SHARDS	EFFECT
Offense	+9 Adaptive Force
Offense	+9 Adaptive Force
Defense	+8 Magic Resist

However, it is good that you take a single defensive shard, magic resist, or armor, to mitigate a little bit of damage if your enemy is aggressive during the early game.

Best Cassiopeia Spells

Flash provides a lot of value for any champion, which is why it is important for Cassiopeia to choose this summoner spell 100% of the time. You can also use flash to combo her other abilities, such as her ultimate (Petrifying Gaze and Miasma), so it is definitely recommended to run flash on all of your games.

BEST SPELLS	ICON
Flash
Barrier

Now, you have two choices as your secondary summoner spell. You can either use ghost or barrier. Most players run barrier as their secondary spell to prevent being burst during team fights, while others use ghost if going against mobile champions. It is your choice if you want more mobility (ghost) or survivability (barrier).

Best Cassiopeia Ability Order

Cassiopeia's skill order is not as complex as other champions. You have to prioritize twin fang every game to get the most out of her kit. It will give you the most DPS and it scales well with conqueror, which is the best rune choice for her.

The next ability that you should prioritize is noxious blast to shorten its cooldown and give more movement speed. Having a higher noxious blast ability level will make it harder for enemies to chase you during skirmishes and team fights. The complete skill order is shown above, just follow it every game and do not stress about choosing her abilities!

Best Cassiopeia Items

Thankfully, even though Cassiopeia is a strong ability damage carry, she is pretty flexible when it comes to items. She is really mobile and focuses on DPS. It may be hard to choose the right items for her because of the tons of choices, but here are the best items that you can buy in all stages of the game!

Best Starter Cassiopeia Items

As stated previously, Cassiopeia relies on DPS, which is why she burns a ton of mana during the early game. 

FIRST ITEM	SECOND ITEM	THIRD ITEM
Tear of the Goddess	Health Potion	Health Potion

To get rid of this problem, the best early items for her are the tear of the goddess and two health potions.

Best Mid Game Cassiopeia Items

Next is the mid game items, which are the most critical when it comes to itemization because it will decide whether you build the right or wrong items. The mid-game is also the point where you counter enemies by buying the right ones until you reach the late game. Here are the recommended mid-game builds for Cassiopeia.

FIRST ITEM	SECOND ITEM	THIRD ITEM	FOURTH ITEM	FIFTH ITEM
Archangel’s Staff	Liandry’s Anguish	Refillable Potion	Control Ward	Seeker’s Armguard

You should have finished building Seraph’s Embrace or Liandry’s Anguish at this point, which is the best out of all the mythic items, to have a maximum DPS as early as possible.

Best Late Game Cassiopeia Items

Arguably the most crucial phase of the game, the late game, is where you should have finalized your Cassiopeia build. League of Legends games are decided by a single-team fight, so getting the right items should be your priority. The items below will let Cassiopeia maximize her DPS and crowd control, making it harder for enemy champions to reposition and catch her during the team fight.

FIRST ITEM	SECOND ITEM	THIRD ITEM	FOURTH ITEM	FIFTH ITEM
Rylai’s Crystal Scepter	Zhonya’s Hourglass	Rabadon’s Deathcap	Demonic Embrace	Seraph’s Embrace

Best Champions To Pair With Cassiopeia

Currently, the best champion to pair with Cassiopeia is Olaf. Cassiopeia has a lot of crowd control, making it easier for Olaf players to chase the enemies and deal maximum damage. The next champion with the second highest win rate when paired with Cassiopeia is Amumu, which also has a great crowd control ultimate.

The last champion is Trundle. He has a high win rate in ranked games for the same reason as Olaf, then can chase enemies much easier because of Cassiopeia's crowd control. All of these champions are a menace when paired with Cassiopeia, so make sure to get officially involved with them at all times!

CHAMPION	WIN RATE %	ICON
Olaf	57.90%
Amumu	56.49%
Trundle	56.45%

Strongest Champions Against Cassiopeia

Seraphine and Vel'koz counter Cassiopeia's strong suit, which is being able to reach the enemy without getting damaged. Both of these champions make it a nightmare for Cassiopeia in all phases of the game.

On the other hand, Diana is also a great counter even though she is a melee champion because she can quickly close the gap against Cassiopeia and kill her with her burst damage.

CHAMPION	WIN RATE %	ICON
Seraphine	55.9%
Velkoz	54.79%
Diana	54.29%

Weakest Champions Against Cassiopeia

These three are the weakest when going against Cassiopeia because they have a short reach, low DPS, and weak sustain, making it easier for Cassiopeia players to abuse them with her abilities.

CHAMPION	WIN RATE %	ICON
Ryze	41.21%
Lissandra	41.84%
Annie	42.86%